Subjective memory complaints in young people; their relationship withobjective cognitive performance and the role of neuroticism / Quejas subjetivas de memoria en jóvenes; su relación con el rendimiento cognitivo objetivo y el papel del neuroticismo

Las percepciones de olvidos recurrentes o episodios de distracción en la vida diaria se denominan quejas subjetivas de memoria (QSM). Su naturaleza se ha estudiado ampliamente en adultos mayores, pero su importancia y relación con el rendimiento neurocognitivo no se han abordado por completo en adultos más jóvenes. Se han sugerido algunos rasgos psicológicos como posibles moderadores de la asociación entre el rendimiento de la memoria objetiva y subjetiva. El primer objetivo de este estudio fue analizar la correspondencia entre la percepción objetiva y subjetiva de los fallos de memoria en jóvenes. En segundo lugar, estudiamos si el rasgo psicológico del neuroticismo podría estar influyendo en esta relación. Para ello, medimos QSM, diferentes dominios cognitivos (memoria episódica y de trabajo y funciones ejecutivas) y neuroticismo en 80 hombres y mujeres jóvenes. Los resultados mostraron que solo la memoria episódica inmediata estaba estadísticamente relacionada con los QSM. Curiosamente, las relaciones negativas entre el rendimiento de la memoria objetiva y subjetiva solo aparecieron en participantes con mayor neuroticismo. Por lo tanto, las quejas de memoria reportadas por los jóvenes podrían reflejar un peor rendimiento de la memoria episódica inmediata, mientras que el neuroticismo jugaría un papel principal en la asociación entre los déficits de memoria y las QSM. Este estudio proporciona datos que pueden ayudar a comprender mejor las QSM en los jóvenes.(AU)

Perceptions of recurrent forgetfulness or episodes of distraction in daily life are referred to as subjective memory complaints (SMCs). Their nature has been extensively studied in older adults, but their significance and relationship with neurocognitive performance have not been fully ad-dressed in younger adults. Some psychological traits have been suggested as possible moderators of the association between objective and subjective memory performance. The first aim of this study was to analyze the corre-spondence between the objective and subjective perception of memory failures in young people. Second, we studied whether the psychological trait of neuroticism could be influencing this relationship. Todo this, we measured SMCs, different cognitive domains (episodic and working memory and executive functions), and neuroticism in 80 young men and women. Results showed that only immediate episodic memory was statisti-cally related to SMCs. Interestingly, the negative relationships between ob-jective and subjective memory performance only appeared in participants with higher neuroticism. Thus, memory complaints reported by young people could reflect poorer immediate episodic memory performance, whereas neuroticism would play a main role in the association between memory deficits and SMCs. This study provides data that can help to bet-ter understand SMCs in young people.(AU)

Effects of chronic physical exercise on executive functions and episodic memory in clinical and healthy older adult populations: a systematic review and meta-analysis protocol.

BACKGROUND: Executive functions (EFs) and episodic memory are fundamental components of cognition that deteriorate with age and are crucial for independent living. While numerous reviews have explored the effect of exercise on these components in old age, these reviews screened and analyzed selected older adult populations, or specific exercise modes, thus providing only limited answers to the fundamental question on the effect of exercise on cognition in old age. This article describes the protocol for a systematic review and multilevel meta-analytic study aiming at evaluating the effectiveness of different types of chronic exercise in improving and/or maintaining EFs and long-term episodic memory in older adults. METHODS AND ANALYSIS: The study protocol was written in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Several databases will be searched. Randomized controlled trials (RCTs) conducted in older adults aged ≥ 60 years providing any kind of planned, structured, and repetitive exercise interventions, and EFs and/or episodic memory measures as outcomes, published in English in peer-reviewed journals and doctoral dissertations will be included. Two independent reviewers will screen the selected articles, while a third reviewer will resolve possible conflicts. The Cochrane risk-of-bias tool will be used to assess the quality of the studies. Finally, data will be extracted from the selected articles, and the formal method of combining individual data from the selected studies will be applied using a random effect multilevel meta-analysis. The data analysis will be conducted with the metafor package in R. DISCUSSION AND CONCLUSION: This review will synthesize the existing evidence and pinpoint gaps existing in the literature on the effects of exercise on EFs and episodic memory in healthy and unhealthy older adults. Findings from this meta-analysis will help to design effective exercise interventions for older adults to improve and/or maintain EFs and episodic memory. Its results will be useful for many researchers and professionals working with older adults and their families. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42022367111.

Childhood urbanicity is associated with emotional episodic memory-related striatal function and common variation in NTRK2.

BACKGROUND: Childhoods in urban or rural environments may differentially affect the risk of neuropsychiatric disorders, possibly through memory processing and neural response to emotional stimuli. Genetic factors may not only influence individuals' choices of residence but also modulate how the living environment affects responses to episodic memory. METHODS: We investigated the effects of childhood urbanicity on episodic memory in 410 adults (discovery sample) and 72 adults (replication sample) with comparable socioeconomic statuses in Beijing, China, distinguishing between those with rural backgrounds (resided in rural areas before age 12 and relocated to urban areas at or after age 12) and urban backgrounds (resided in cities before age 12). We examined the effect of childhood urbanicity on brain function across encoding and retrieval sessions using an fMRI episodic memory paradigm involving the processing of neutral or aversive pictures. Moreover, genetic association analyses were conducted to understand the potential genetic underpinnings that might contribute to memory processing and neural mechanisms influenced by early-life urban or rural environments. RESULTS: Episodic memory retrieval accuracy for more difficult neutral stimuli was similar between those with urban and rural childhoods, whereas aversive stimuli elicited higher retrieval accuracy in the urban group (P = 0.023). For aversive stimuli, subjects with urban childhood had relatively decreased engagement of the striatum at encoding and decreased engagement of the hippocampus at retrieval. This more efficient striatal encoding of aversive stimuli in those with urban childhoods was associated with common variation in neurotrophic tyrosine kinase receptor type 2 (NTRK2) (right striatum: P = 1.58×10-6). These findings were confirmed in the replication sample. CONCLUSIONS: We suggest that this differential striatal processing of aversive stimuli observed in individuals with urban or rural childhoods may represent mechanisms by which childhood urbanicity may affect brain circuits, heightening behavioral responses to negative stressors associated with urban environments. NTRK2-associated neural processes in the striatum may play a role in these processes.

Increases in pre-stimulus theta and alpha oscillations precede successful encoding of crossmodal associations.

A central aspect of episodic memory is the formation of associations between stimuli from different modalities. Current theoretical approaches assume a functional role of ongoing oscillatory power and phase in the theta band (3-7 Hz) for the encoding of crossmodal associations. Furthermore, ongoing activity in the theta range as well as alpha (8-12 Hz) and low beta activity (13-20 Hz) before the presentation of a stimulus is thought to modulate subsequent cognitive processing, including processes that are related to memory. In this study, we tested the hypothesis that pre-stimulus characteristics of low frequency activity are relevant for the successful formation of crossmodal memory. The experimental design that was used specifically allowed for the investigation of associative memory independent from individual item memory. Participants (n = 51) were required to memorize associations between audiovisual stimulus pairs and distinguish them from newly arranged ones consisting of the same single stimuli in the subsequent recognition task. Our results show significant differences in the state of pre-stimulus theta and alpha power between remembered and not remembered crossmodal associations, clearly relating increased power to successful recognition. These differences were positively correlated with memory performance, suggesting functional relevance for behavioral measures of associative memory. Further analysis revealed similar effects in the low beta frequency ranges, indicating the involvement of different pre-stimulus-related cognitive processes. Phase-based connectivity measures in the theta band did not differ between remembered and not remembered stimulus pairs. The findings support the assumed functional relevance of theta band oscillations for the formation of associative memory and demonstrate that an increase of theta as well as alpha band oscillations in the pre-stimulus period is beneficial for the establishment of crossmodal memory.

The influence of the precuneus on the medial temporal cortex determines the subjective quality of memory during the retrieval of naturalistic episodes.

Memory retrieval entails dynamic interactions between the medial temporal lobe and areas in the parietal and frontal cortices. Here, we tested the hypothesis that effective connectivity between the precuneus, in the medial parietal cortex, and the medial temporal cortex contributes to the subjective quality of remembering objects together with information about their rich spatio-temporal encoding context. During a 45 min encoding session, the participants were presented with pictures of objects while they actively explored a virtual town. The following day, under fMRI, participants were presented with images of objects and had to report whether: they recognized the object and could remember the place/time of encoding, the object was familiar only, or the object was new. The hippocampus/parahippocampus, the precuneus and the ventro-medial prefrontal cortex activated when the participants successfully recognized objects they had seen in the virtual town and reported that they could remember the place/time of these events. Analyses of effective connectivity showed that the influence exerted by the precuneus on the medial temporal cortex mediates this effect of episodic recollection. Our findings demonstrate the role of the inter-regional connectivity in mediating the subjective experience of remembering and underline the relevance of studying memory in contextually-rich conditions.

Guided recall of positive autobiographical memories increases anticipated pleasure and psychological resources, and reduces depressive symptoms: a replication and extension of a randomised controlled trial of brief positive cognitive-reminiscence therapy.

Reminiscence-based interventions focus on recalling autobiographical memories and reflective reasoning to develop a healthy and adaptive view of oneself and one's life. This study aimed to replicate the effects of a three-session, group-based, positive-memory version of cognitive-reminiscence therapy (CRT) on psychological resources and mental well-being and extend the findings to anticipated pleasure. The participants (N = 75, Mage = 43.7 (SD = 16.7), 60% females) were randomised to CRT or control group. Anticipated pleasure, psychological resources (schemas of positive self-esteem, self-efficacy, meaning in life, optimism), mental well-being (depression, anxiety, and stress symptoms) and theorised change processes (automatic negative thoughts, awareness of narrative identity) were assessed. Relative to the control group, the CRT group reported significantly higher anticipated pleasure (d = 0.76-0.93) and psychological resources of self-esteem, self-efficacy, and optimism (d's = 0.58-0.99) at post-CRT and follow-up, and lower depressive symptoms post-CRT and at follow-up (d = 0.56-0.67). Findings on meaning in life and negative automatic thinking were partially replicated. This study replicates findings of the effectiveness of this intervention for improving psychological resources such as self-worth, confidence and optimism and depressive symptoms, and indicates additional effects on anticipated pleasure. CRT may serve as a standalone intervention, or as an adjunct "memory booster" for interventions focused on future thinking and related anticipated reward.

Spatial context scaffolds long-term episodic richness of weaker real-world autobiographical memories in both older and younger adults.

Remembering life experiences involves recalling not only what occurred (episodic details), but also where an event took place (spatial context), both of which decline with age. Although spatial context can cue episodic detail recollection, it is unknown whether initially recalling an event alongside greater reinstatement of spatial context protects memory for episodic details in the long term, and whether this is affected by age. Here, we analysed 1079 personally-experienced, real-world events from 29 older adults and 12 younger adults. Events were recalled first on average 6 weeks after they occurred and then again on average 24 weeks after they occurred. We developed a novel scoring protocol to quantify spatial contextual details and used the established Autobiographical Interview to quantify episodic details. We found improved recall of episodic details after a delay if those details had initially been recalled situated in greater spatial context. Notably, for both older and younger adults, this preservation was observed for memories initially recalled with low, but not high, numbers of episodic details, suggesting that spatial context aided episodic retrieval for memories that required more support. This work supports the notion that spatial context scaffolds detail-rich event recollection and inspires memory interventions that leverage this spatial scaffold.

EEG decoders track memory dynamics.

Encoding- and retrieval-related neural activity jointly determine mnemonic success. We ask whether electroencephalographic activity can reliably predict encoding and retrieval success on individual trials. Each of 98 participants performed a delayed recall task on 576 lists across 24 experimental sessions. Logistic regression classifiers trained on spectral features measured immediately preceding spoken recall of individual words successfully predict whether or not those words belonged to the target list. Classifiers trained on features measured during word encoding also reliably predict whether those words will be subsequently recalled and further predict the temporal and semantic organization of the recalled items. These findings link neural variability predictive of successful memory with item-to-context binding, a key cognitive process thought to underlie episodic memory function.

Efficacy of memory protocols in 9- to 89-year-olds' memory for prior contacts.

Memory for prior contacts has several important applied implications, including contact tracing (for communicable diseases). Incomplete episodic memory reports, which occur across the developmental lifespan but are particularly relevant for children and older adults, may hamper such efforts. Prior research has shown that cognitively informed memory techniques may bolster recall of contacts in adults, but that work has not addressed the developmental efficacy of these techniques. Here we evaluated the effectiveness of such techniques for familiar and unfamiliar contacts within a sample of 9- to 89-year-olds in the context of an ongoing pandemic. The tested memory techniques bolstered recall across the lifespan, irrespective of whether the interview was conducted live with an interviewer or via a self-led interview. Children, emerging adults, and adults did not reveal any differences in memory productivity, however, older adults recalled fewer contacts. Implications for theory and application are discussed.

Effectiveness of Electroencephalography Neurofeedback for Improving Working Memory and Episodic Memory in the Elderly: A Meta-Analysis.

Background and Objective: Existing evidence indicates the potential benefits of electroencephalography neurofeedback (NFB) training for cognitive function. This study aims to comprehensively review all available evidence investigating the effectiveness of NFB on working memory (WM) and episodic memory (EM) in the elderly population. Material and Methods: A systematic search was conducted across five databases to identify clinical trials examining the impact of NFB on memory function in healthy elderly individuals or those with mild cognitive impairment (MCI). The co-primary outcomes focused on changes in WM and EM. Data synthesis was performed using a random-effects meta-analysis. Results: Fourteen clinical trials (n = 284) were included in the analysis. The findings revealed that NFB was associated with improved WM (k = 11, reported as Hedges' g = 0.665, 95% confidence [CI] = 0.473 to 0.858, p < 0.001) and EM (k = 12, 0.595, 0.333 to 0.856, p < 0.001) in the elderly, with moderate effect sizes. Subgroup analyses demonstrated that NFB had a positive impact on both WM and EM, not only in the healthy population (WM: k = 7, 0.495, 0.213 to 0.778, p = 0.001; EM: k = 6, 0.729, 0.483 to 0.976, p < 0.001) but also in those with MCI (WM: k = 6, 0.812, 0.549 to 1.074, p < 0.001; EM: k = 6, 0.503, 0.088 to 0.919, p = 0.018). Additionally, sufficient training time (totaling more than 300 min) was associated with a significant improvement in WM (k = 6, 0.743, 0.510 to 0.976, p < 0.001) and EM (k = 7, 0.516, 0.156 to 0.876, p = 0.005); however, such benefits were not observed in groups with inadequate training time. Conclusions: The results suggest that NFB is associated with enhancement of both WM and EM in both healthy and MCI elderly individuals, particularly when adequate training time (exceeding 300 min) is provided. These findings underscore the potential of NFB in dementia prevention or rehabilitation.

Structure-Function Interactions in the Hippocampus and Prefrontal Cortex Are Associated with Episodic Memory in Healthy Aging.

Aging comes with declines in episodic memory. Memory decline is accompanied by structural and functional alterations within key brain regions, including the hippocampus and lateral prefrontal cortex, as well as their affiliated default and frontoparietal control networks. Most studies have examined how structural or functional differences relate to memory independently. Here we implemented a multimodal, multivariate approach to investigate how interactions between individual differences in structural integrity and functional connectivity relate to episodic memory performance in healthy aging. In a sample of younger (N = 111; mean age, 22.11 years) and older (N = 78; mean age, 67.29 years) adults, we analyzed structural MRI and multiecho resting-state fMRI data. Participants completed measures of list recall (free recall of words from a list), associative memory (cued recall of paired words), and source memory (cued recall of the trial type, or the sensory modality in which a word was presented). The findings revealed that greater structural integrity of the posterior hippocampus and middle frontal gyrus were linked with a pattern of increased within-network connectivity, which together were related to better associative and source memory in older adulthood. Critically, older adults displayed better memory performance in the context of decreased hippocampal volumes when structural differences were accompanied by functional reorganization. This functional reorganization was characterized by a pruning of connections between the hippocampus and the limbic and frontoparietal control networks. Our work provides insight into the neural mechanisms that underlie age-related compensation, revealing that the functional architecture associated with better memory performance in healthy aging is tied to the structural integrity of the hippocampus and prefrontal cortex.

Peering into the future: Eye movements predict neural repetition effects during episodic simulation.

Imagining future scenarios involves recombining different elements of past experiences into a coherent event, a process broadly supported by the brain's default network. Prior work suggests that distinct brain regions may contribute to the inclusion of different simulation features. Here we examine how activity in these brain regions relates to the vividness of future simulations. Thirty-four healthy young adults imagined future events with familiar people and locations in a two-part study involving a repetition suppression paradigm. First, participants imagined events while their eyes were tracked during a behavioral session. Immediately after, participants imagined events during MRI scanning. The events to be imagined were manipulated such that some were identical to those imagined in the behavioral session while others involved new locations, new people, or both. In this way, we could examine how self-report ratings and eye movements predict brain activity during simulation along with specific simulation features. Vividness ratings were negatively correlated with eye movements, in contrast to an often-observed positive relationship with past recollection. Moreover, fewer eye movements predicted greater involvement of the hippocampus during simulation, an effect specific to location features. Our findings suggest that eye movements may facilitate scene construction for future thinking, lending support to frameworks that spatial information forms the foundation of episodic simulation.

Retracted memories in the general population: are there differences between eastern and western countries?

The main purpose of the current studies was to examine retracted experiences in the general population from various cultural backgrounds. More specifically, in two studies, we examined the details of memory retraction experiences, the reasons for retraction, and the outcomes of retraction in participants from China and other countries, mainly the United States of America. It was found that memory retraction experiences appeared to be quite common. In the sample of Chinese participants (Study 1: N = 1380), 50.58% reported at least one such an experience, whereas in respondents from other countries (Study 2; N = 425), a significantly lower but still substantial prevalence rate of 35% was found. In general, the retracted memories predominantly involved positive events and some respondents experienced pressure during the withdrawal. Social feedback and event plausibility were the two main reasons for the withdrawal. Compared to recollection scores, belief scores decreased significantly after withdrawal, and some respondents even formed nonbelieved memories. After retracting the memories, most respondents felt they gained benefits (e.g., they had resolved a psychological problem that had bothered them for years). These studies give us a more general understanding of retracted memory experiences in the general population.

The positive dimension of schizotypy is associated with self-report measures of autobiographical memory and future thinking but not experimenter-scored indices.

ABSTRACTThe ability to remember our past and to imagine the future are critical to our sense of self. Previous research has indicated that they are disrupted in schizophrenia. However, it is unclear (i) whether this is found when examining experimenter-scored indices of content and/or participants' self-report of phenomenological characteristics, and (ii) how these abilities might be related to symptoms. This study sought to address these questions by taking a dimensional approach and measuring positive and negative schizotypal experiences in healthy people (n = 90). Participants were given cue words. For some, they remembered an event from the past and for others they generated an event in the future. No significant relationships were found with any aspect of schizotypy when participants' descriptions were scored by the experimenter according to a standardised episodic content measure. In contrast, several significant positive correlations were observed for past memory and future thinking when examining the positive dimension of schizotypy and participants' ratings, particularly to sensory characteristics of the experience and mental pre- or reliving. These results indicate enhanced subjective experiences of autobiographical memory and future thinking in those who report delusional and hallucinatory-like occurrences, which might be linked to mental imagery or metacognitive alterations.

Emotional and temporal order effects - a comparison between word-cued and important autobiographical memories recall orders.

The retrieval mechanisms associated with the recall of autobiographical memories (AMs) may differ according to the cueing method used to elicit AMs. In the present study, we provide a systematic comparison between word-cued and important AMs in terms of two recall order effects, namely a temporal and an emotional order effect. The sample comprised 104 adults aged between 59 and 90 years. On two measurement occasions, participants recalled up to 20 word-cued and 15 important AMs. For each memory, participants provided their age at the time when the event occurred (age-at-event) and rated its emotionality. Order effects were analysed based on multivariate multilevel model with autoregressive effects for emotionality and age-at-event, respectively. Whereas word-cued AMs showed a stronger emotional order effect, important AMs were recalled temporarily ordered. Individuals differed in the extent to which they ordered AMs along a temporal or emotional dimension. These differences could partly be explained by personality traits. For instance, higher scores on neuroticism were associated with a stronger emotional order effect in both memory types. Findings are discussed in terms of the retrieval mechanisms that are involved in the recall of word-cued and important memory recall and how they may be affected by personality.

Barcoding of episodic memories in the hippocampus of a food-caching bird.

The hippocampus is critical for episodic memory. Although hippocampal activity represents place and other behaviorally relevant variables, it is unclear how it encodes numerous memories of specific events in life. To study episodic coding, we leveraged the specialized behavior of chickadees-food-caching birds that form memories at well-defined moments in time whenever they cache food for subsequent retrieval. Our recordings during caching revealed very sparse, transient barcode-like patterns of firing across hippocampal neurons. Each "barcode" uniquely represented a caching event and transiently reactivated during the retrieval of that specific cache. Barcodes co-occurred with the conventional activity of place cells but were uncorrelated even for nearby cache locations that had similar place codes. We propose that animals recall episodic memories by reactivating hippocampal barcodes. Similarly to computer hash codes, these patterns assign unique identifiers to different events and could be a mechanism for rapid formation and storage of many non-interfering memories.

A lifespan study of the confidence-accuracy relation in working memory and episodic long-term memory.

The relation between an individual's memory accuracy and reported confidence in their memories can indicate self-awareness of memory strengths and weaknesses. We provide a lifespan perspective on this confidence-accuracy relation, based on two previously published experiments with 320 participants, including children aged 6-13, young adults aged 18-27, and older adults aged 65-77, across tests of working memory (WM) and long-term memory (LTM). Participants studied visual items in arrays of varying set sizes and completed item recognition tests featuring 6-point confidence ratings either immediately after studying each array (WM tests) or following a long period of study events (LTM tests). Confidence-accuracy characteristic analyses showed that accuracy improved with increasing confidence for all age groups and in both WM and LTM tests. These findings reflect a universal ability across the lifespan to use awareness of the strengths and limitations of one's memories to adjust reported confidence. Despite this age invariance in the confidence-accuracy relation, however, young children were more prone to high-confidence memory errors than other groups in tests of WM, whereas older adults were more susceptible to high-confidence false alarms in tests of LTM. Thus, although participants of all ages can assess when their memories are weaker or stronger, individuals with generally weaker memories are less adept at this confidence-accuracy calibration. Findings also speak to potential different sources of high-confidence memory errors for young children and older adults, relative to young adults. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Isolating the effects of visual imagery on prospective memory.

Two experiments investigated the role of visual imagery in prospective memory (PM). In experiment 1, 140 participants completed a general knowledge quiz which included a PM task of writing a letter "X" next to any questions that referred to space. Participants either visualised themselves performing this task, verbalised an implementation intention about the task, did both, or did neither. Performance on the PM task was enhanced in both conditions involving visual imagery but not by implementation intentions alone. In experiment 2, 120 participants imagined themselves writing a letter "X" next to questions about space, or in a bizarre imagery condition imagined themselves drawing an alien next to those questions. Relative to the control condition, PM was significantly enhanced when participants imagined writing a letter "X" next to the target questions, but not by the bizarre imagery task. The findings indicate that the robust effects of imagery observed in retrospective memory also extend to PM.

Memristor-based circuit design of episodic memory neural network and its application in hurricane category prediction.

Episodic memory, as a type of long-term memory (LTM), is used to learn and store the unique personal experience. Based on the episodic memory biological mechanism, this paper proposes a bionic episodic memory memristive neural network circuit. The proposed memristive neural network circuit includes a neocortical module, a parahippocampal module and a hippocampus module. The neocortical module with the two paths structure is used to receive the sensory signal, and is also used to separate and transmit the spatial information and the non-spatial information involved in the sensory signal. The parahippocampal module is composed of the parahippocampal cortex-MEA and the perirhinal cortex-LEA, which receives the two types of information from the neocortical module respectively. As the last module, the hippocampus module receives and integrates the output information of the parahippocampal module as well as generates the corresponding episodic memory. Meanwhile, the specific scenario information with the certain temporal signal from the generated episodic memory is also extracted by the hippocampus module. The simulation results in PSPICE show that the proposed memristive neural network circuit can generate the various episodic memories and extract the specific scenario information successfully. By configuring the memristor parameters, the proposed bionic episodic memory memristive neural network circuit can be applied to the hurricane category prediction, which verifies the feasibility of this work.

FMRI correlates of autobiographical memory: Comparing silent retrieval with narrated retrieval.

FMRI studies of autobiographical memory (AM) retrieval typically ask subjects to retrieve memories silently to avoid speech-related motion artifacts. Recently, some fMRI studies have started to use overt (spoken) retrieval to probe moment-to-moment retrieved content. However, the extent to which the overt retrieval method alters fMRI activations during retrieval is unknown. Here we examined this question by eliciting unrehearsed AMs during fMRI scanning either overtly or silently, in the same subjects, in different runs. Differences between retrieval modality (silent vs. narrated) included greater activation for silent retrieval in the anterior hippocampus, left angular gyrus, PCC, and superior PFC, and greater activation for narrated retrieval in speech production regions, posterior hippocampus, and the DLPFC. To probe temporal dynamics, we divided each retrieval period into an initial search phase and a later elaboration phase. The activations during the search and elaboration phases were broadly similar regardless of modality, and these activations were in line with previous fMRI studies of AM temporal dynamics employing silent retrieval. For both retrieval modalities, search activated the hippocampus, mPFC, ACC, and PCC, and elaboration activated the left DLPFC and middle temporal gyri. To examine content-specific reactivation during retrieval, the timecourse of narrated memory content was transcribed and modeled. We observed dynamic activation associated with object content in the lateral occipital complex, and activation associated with scene content in the retrosplenial cortex. The current findings show that both silent and narrated AMs activate a broadly similar memory network, with some key differences, and add to current knowledge regarding the content-specific dynamics of AM retrieval. However, these observed differences between retrieval modality suggest that studies using overt retrieval should carefully consider this method's possible effects on cognitive and neural processing.